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CalcuSyn 丨 混合药物分析软件

CalcuSyn是目前市场上运用极为广泛的混合药物分析软件,该软件可以自动量化各种药物作用过程,比如:协同作用和抑制作用等。目前在临床医学上混合药物正逐渐广泛运用于癌症、艾滋病等疾病的治疗。它具有多种药物的剂量效应计算,数据可处理两个单独药品、恒定的比例或非恒定比率的组合。CalcuSyn采集的数据可以直接通过键盘或者导入文件形式输入到系统中或者直接进入分析引擎中。处理的数据既可以是单一药物的也可以是混合药物的恒定比率或非恒定比率。同时根据数据自动绘图,并能得到所有药物和药物相互作用的详细分析报告,包括组合指数和能谱分析。该软件能打印各种结果和图表,能导出到电子表格、Word进行进一步处理中等。软件含PDF的介绍手册和帮助功能。该软件已经被数国内外很多实验室和制药公司广泛应用,成为混合药物研究中必不可少的工具。


单药和多药的剂量-效应分析仪



CalcuSyn 2.0版是组合药物效应的权威分析仪,能够自动量化协同作用和抑制等现象。混合药物治疗在癌症,艾滋病等的治疗中变得越来越普遍,而CalcuSyn用于在该领域建立疗效的最广泛使用的软件。它使用TC Chou和P.Talaly(Trends Pharmacol.Sci.4,450-454)描述中位效应方法进行多种药物剂量效应计算。


CalcuSyn可以轻松地与其他软件集成。可以通过键盘或文件导入数据输入网格或直接输入分析引擎。使用网格时,可以通过向导处理数据,使新用户可以轻松访问该软件。


可以针对单个药物和恒定比例或非恒定比例的药物组合处理数据。CalcuSyn自动绘制数据图并生成报告,提供所有药物的汇总统计数据以及药物相互作用的详细分析,包括组合指数和EDx(对于x的任何值)。可以使用蒙特卡罗模拟或高精度代数估计算法计算EDx和CI的准确度估计值。CalcuSyn绘制的图包括剂量效应,中值效应,等效线图和CI效应。


CalcuSyn 2.0版具有撤销和重做工具。可灵活安排打印结果和图表,并将其导出到电子表格,文字处理程序,图形软件包等。一本综合手册以软件形式提供.pdf,并有详细的帮助文件。这些分析方法的理论基础,包括结果的统计处理。CalcuSyn已经在数百家学术实验室和制药公司中使用,对于药物混合物的研究是不可或缺的。


【英文介绍】

CalcuSyn Version 2.0 is the definitive analyzer of combined drug effects, able automatically to quantify phenomena such as synergism and inhibition. Mixed drug treatment is becoming common in the treatment of cancer, AIDS etc, and CalcuSyn is the most widely used software for establishing efficacy in this field. It performs multiple drug dose-effect calculations using the Median Effect methods described by T-C Chou and P. Talalay (Trends Pharmacol. Sci. 4, 450-454).

CalcuSyn can easily be integrated with other software. Data can be entered via the keyboard or file import either into the grid or directly into the analysis engine. When the grid is used, data can be processed through wizards which make the software easily accessible to new users.

Data can be processed both for individual drugs and for constant-ratio or non-constant-ratio combinations of drugs. CalcuSyn automatically graphs the data and produces reports giving summary statistics on all drugs plus detailed analysis of drug interactions including the Combination Index and EDx (for any value of x). Estimates of accuracy of EDx and CI can be calculated with Monte Carlo simulations or by a highly accurate algebraic estimation algorithm. The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect. All data and results are easily accessible by mouse-click on the contents tree.

CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, graphics packages etc. A comprehensive manual is supplied as .pdf with the software and there is a detailed Help file. These give a thorough account of the theoretical basis of the analysis methods including the statistical treatment of results. Already used in hundreds of academic labs and pharmaceutical companies, CalcuSyn is indispensable for the study of drug mixtures.

General Science Range(普通的科学范围)

FigSys- Publication quality graph plotting and data analysis.

Stat-200- General statistics and graphics package.

UnGraph- Digitizer program which gives X,Y coordinates of lines or points on scanned

images.

Biomedical Range(生物医学范围)

AssayZap- Universal assay calculator for RIA, ELISA, IRMA, colorimetric or any other type

of assay.

CalcuSyn- Dose-effect analysis.

EnzFitter- Curve fitting and analysis of enzyme kinetics experiments.

QuantiScan- Densitometry using ordinary office scanners.

Educational / Teaching Range(教育/教学范围)

NeuroSim- Neurophysiology simulations.

CardioLab- Simulation of in vivo cardiovascular pharmacology experiments.

Ileum- Simulation of experiments on the isolated Guinea-pig Ileum.

 

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